Postdoctoral Fellow position in single-molecule biophysics at UCL, London

Applications are invited for a Postdoctoral Research Fellow in the research team led by Dr Graeme King ( at University College London.

The King lab is an interdisciplinary lab that seeks to understand the fundamental mechanisms that underpin genome organisation and gene regulation. To this end, we use a combination of single-molecule biophysical techniques, biochemistry and quantitative data analysis. We are especially interested in understanding how changes in genome architecture and topology drive genomic processes. We are based in the Department of Structural and Molecular Biology at UCL, which is part of the Division of Biosciences (UCL Biosciences | UCL Division of Biosciences - UCL – University College London), one of the world’s foremost centres for research and teaching in the biological sciences. We are also a member of the UCL/Birkbeck Institute of Structural and Molecular Biology (, which is one of the internationally premier institutions in multidisciplinary life sciences.

The successful applicant will engage in an ambitious and interdisciplinary research programme to investigate mechanisms for regulating genome organisation. The research will involve the use of cutting-edge single-molecule biophysical techniques, including optical tweezers and fluorescence imaging assays. In parallel, the Fellow will implement a novel biochemical strategy to prepare the relevant biological samples for the single-molecule experiments.

The position is funded by the Leverhulme Trust ( and is available for 3 years, from 1st March 2023.

About You

Applicants should hold a PhD (or be close to completion) in either biophysics, physics, physical chemistry, biochemistry, or a related area. You should have expertise in biophysics, biochemistry and quantitative data analysis. Practical experience of single-molecule biophysical techniques, nucleic acid biochemistry and DNA-protein studies is desirable. You should be self-motivated and have a strong ability and interest in conducting interdisciplinary research. Excellent interpersonal and communication skills and a strong publication record are essential. You should be well-organised and have the ability to work both independently and as part of a team.

We appreciate that some well-suited candidates may not always feel able to judge if they meet all of the requirements. If you are in doubt, we encourage you to get in touch.

Our commitment to Equality, Diversity, and Inclusion

We are committed to equality of opportunity, fairness and inclusivity. We particularly encourage applications from candidates who are underrepresented in scientific research. Our department holds an Athena SWAN Bronze award, in recognition of our commitment to advancing gender equality.

Application Process

Applications should be made online, via the following link:

As part of your application, you will be required to upload a supporting statement and CV. Your supporting statement should explain your motivation for the position and describe how you meet the criteria listed in the job description.

Informal enquiries should be addressed to Dr Graeme King (

The closing date for applications is 23:59, Sunday 15 January 2023. Interviews will be held as soon as possible thereafter.

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